Each 5 ml contains:
Ambroxol Hydrochloride I.P............. 15 mg
Terbutaline Sulphate I.P…………....… 1.25 mg
Guaiphenesin I.P ………………………… 50 mg
Menthol I.P ………………………………… 1 mg
Flavoured Syrup Base…………………… Q.S.
Varnituss Syrup is a combination of Terbutaline sulphate, ambroxol hydrochloride and Guaiphenesin.
Terbutaline is a selective beta 2 -adrenergic agonist which predominantly stimulates beta 2-receptors, thus producing relaxation of bronchial smooth muscle.
Ambroxol possesses mucokinetic (improvement in mucus transport) and secretolytic (liquifies secretions) properties. It promotes the removal of tenacious secretions in the respiratory tract and reduces mucus stasis (arresting the secretion of mucus). Besides that, Ambroxol also exhibits anti-oxidant activity.
Guaiphenesin, by increasing respiratory tract fluid, reduces the viscosity of tenacious secretions and acts as an expectorant. Another possible mechanism by which it acts is by increasing the water bonding in the sputum, thereby decreasing its viscosity and leading to an increase in mucokinesis. Guaiphenesin is effective in both productive and non-productive coughs.
Menthol gives soothing effect.
Varnituss Syrup is indicated for clinical relief of cough associated with bronchitis, bronchial asthma, emphysema and other bronchopulmonary disorders where bronchospasm, mucous plugging and problems of expectoration co-exist.
Hypersensitivity to any of the components of the formulation. It should not be used in patients with pre-existing ischaemic heart disease or those patients with significant risk factors for ischaemic heart disease.
It is also contraindicated in patients with gastric ulceration.
Varnituss Syrup: Bottle pack of 100 ml