Varnituss-DS : Varni Pharmaceuticals

Varnituss-DS

(DEXTROMETHORPHAN HYDROBROMIDE,PHENYLEPHRINE HYDROCHLORIDE & CHLORPHENIRAMINE MALEATE SYRUP)

DETAILS

Each 5 ml contains:

Dextromethorphan Hydrobromide I.P......... 10 mg
Phenylephrine Hydrochloride I.P................. 5 mg
Chlorpheniramine Maleate I.P...................... 2 mg
Flavoured Syrup Base………….............…….... Q.S.

DESCRIPTION

Varnituss-DS Syrup is a combination of Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride and Chlorpheniramine Maleate.

Chlorpheniramine maleate possesses H1 antihistaminic activity and mild anticholinergic and sedative effects.Chlorpheniramine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine hydrochloride is an oral sympathomimetic amine that acts as a decongestant to respiratory tract mucous membranes. Phenylephrine hydrochlorideshrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. Dextromethorphan hydrobromide is a non-narcotic antitussive with effectiveness equal to codeine. It acts in the medulla oblongata to elevate the cough threshold.

INDICATIONS

Varnituss-DS Syrup is indicated for relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.

DOSAGE AND ADMINISTRATION

Age Group	Daily Dose
Adults and Children 12 years of age and older	1 teaspoonful (5 mL) every 4 to 6 hours, not to exceed 6 teaspoonfuls in 24 hours.
Children 6 to under 12 years of age	1/2 teaspoonful (2.5 mL) every 4 to 6 hours, not to exceed 3 teaspoonfuls in 24 hours.
Children 2 to under 6 years of age	1/4 teaspoonful (1.25 mL) every 4 to 6 hours, not to exceed 1.5 teaspoonfuls in 24 hours.
Not recommended for use in children under 2 years of age.

CONTRAINDICATIONS

Patients with hypersensitivity or idiosyncrasy to any of its ingredients.

Sympathomimetic amines are contraindicated in patients with severe hypertension, severe coronary artery disease and patients on monoamine oxidase (MAO) inhibitor therapy. Antihistamines are contraindicated in patients with narrow angle glaucoma, urinary retention, peptic ulcer and during an asthma attack. Dextromethorphan should not be used in patients receiving a monoamine oxidase inhibitor (MAOI) or for 2 weeks after stopping the MAOI drug.

PRESENTATION

Varnituss-DS Syrup: Bottle pack of 100 ml